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| 1650 |
| | | James Ussher, archbishop of Armagh, calculates that creation began on Sunday, October 23, 4004 BC | |
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| 1650 |
| | | To protect their market, the Dutch destroy all clove trees in the Moluccas except on two islands, Amboina and Ternate | |
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| c. 1650 |
| | | A German burgomaster, Otto von Guericke, devises an air pump capable of creating a vacuum | |
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| 1650 |
| | | The Dalai Lama declares that his teacher is also an incarnation of a future Buddha, and that he is to be known as Panchen | |
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| 1650 |
| | | The poems of Massachusetts author Anne Bradstreet are published in London under the title The Tenth Muse Lately Sprung Up in America | |
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| 1651 |
| | | Charles II returns to Scotland and is crowned king of Scots in the traditional manner at Scone | |
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| 1651 |
| | | Parliament in England passes the first of several Navigation Acts designed to reserve international trade for English ships | |
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| 1651 |
| | | Charles II is defeated by Cromwell at Worcester and escapes in disguise to France | |
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| 1652 |
| | | Nikon becomes patriarch of all Russia and introduces reforms which cause the Old Believers to form a breakaway sect | |
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| 1652 |
| | | Scotland and England are merged under English parliamentary rule, in a forced union which lasts eight years | |
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